An Introduction to 11β-HSD1 Inhibition

Aside from their oft-exploited anti-inflammatory properties, glucocorticoids such as cortisol have number of other effects. They inhibit the uptake of glucose into muscle, shift homeostasis into a catabolic state, and promote the deposition of fat.
High levels of glucocorticoids cause visceral obesity (fat around the internal abdominal organs), insulin resistance, type 2 diabetes, adverse cholesterol levels, high blood pressure, and cardiac problems; so called “metabolic syndrome”.

Metabolic syndrome Continue reading

PEA: A natural analgesic whose time has come

Palmitoylethanolamide (PEA) is a naturally-occurring anti-inflammatory and analgesic fatty acid amide. PEA is formed locally at sites of tissue inflammation as a defense and repair reaction. It modulates mast cell activity (hyperactive in inflammatory conditions) and activated glia cells (non-neuronal brain cells).

Palmitoylethanolamide (PEA)

Palmitoylethanolamide (PEA)

An interesting paper on palmitoylethanolamide (PEA) was published recently in the Journal of Pain Research. The author, Jan Keppel of the University of Witten/Herdecke in Germany, summarizes the advances in the scientific understanding of PEA and related compounds that occurred over the last 60 years or so, and makes a number of interesting observations, though some of the conclusions reached may be challenged.

Check out the video abstract below for a quick rundown, or read the full text here.


Continue reading

Update: Two Purity First products may contain “Dimethyltestosterone”

As mentioned in our previous blog post FDA officials recently identified the presence of two well known designer steroids, dimethazine and superdrol, in Purity First’s Healthy Life Chemistry B-50 product.

Further FDA testing has noted the additional detection of traces of something they suspect to be “dimethyltestosterone” in Purity First’s “Multi-Mineral” and “Vitamin C” products. [1] Continue reading

Healthy Life Chemistry B-50 contains Superdrol and Dimethazine

healthy life chemistry by purity firstIn a rather spectacular – not to mention ironic – blunder, a Vitamin B supplement from a supplement company called “Purity First” appears to have been contaminated with the designer steroids Methasteron and Dimethazine. Methasteron, better known as Superdrol, became a scheduled drug in 2012.

The FDA has received reports of 29 adverse incidents associated with the use of Healthy Life Chemistry By Purity First B-50. These reports include fatigue, muscle cramping, and myalgia (muscle pain), as well as abnormal laboratory findings for liver and thyroid function, and cholesterol levels.

Females who used this product reported unusual hair growth and missed menstruation, and males who used the product reported impotence and findings of low testosterone.

Some of the cases reported have resulted in hospitalization, but there were no reports of death or acute liver failure.

While this is almost undoubtedly a horrible accident caused primarily by carelessness on the part of their (presumably) Chinese supplier or contract manufacturer (and their own failure to perform adequate testing), it’s likely to have unpleasant ramifications for the owners of the inappropriately named “Purity First”.

More information: FDA warns consumers about health risks with Healthy Life Chemistry dietary supplement

New Products: Desoxytestosterone, Triacetyladenosine, and Oneiromancer

Several interesting new products have hit the supplement and prohormone markets recently. New prohormones available include desoxytestosterone acetate, and new supplements include the “pump product” triacetyladenosine, and the sleep/dream formula Oneiromancer.

Desoxytestosterone Acetate:

Structural Image:
2-androstenol Ac
Nomenclature:
17β-acetoxy-5α-androst-2-ene

Desoxytestosterone is the non-17a-methylated analogue of desoxymethyltestosterone. Desoxymethyltestosterone is better known as madol or pheraplex, so desoxytestosterone is sometimes referred to as “unmethylated phera”.
Desoxytestosterone has an anabolic:androgenic ratio of 160:60 vs. testosterone by subcutaneous injection. [1]
Desoxytestosterone acetate first appeared on the market as a component of AX’s “3-AD”, and is currently available to pre-order as a raw powder from PHF Supplements. The acetate ester will enhance solubility significantly.

Triacetyladenosine

Structural Image:
triacetyladenosine
Adenosine is a cellular signalling molecule that regulates muscular blood flow and glucose uptake. Adenosine itself has a very short half life and is readily subjected to metabolic inactivation by the enzyme adenosine deaminase. [2][3] The 3 acetyl groups of triacetyladenosine slow the rate of metabolism and elimination of the adenosine molecule in the body. These chemical changes also permit greater lipid solubility to allow for better accessibility to the body via a topical formulation.

Prototype Nutrition has recently introduced triacetyladenosine as a capped product for oral use. The ingredient can also be found in two of Patrick Arnold’s other formulations; E-Pharm Pump Spray and E-Pharm Joint Force.

Oneiromancer

silene capensisHemidesmus_indicus_roots
Oneiromancer from Antaeus Labs is promoted as a dream/sleep supplement. It contains extracts of the shamanistic herbs Silene Capensis and Synaptolepis Kirkii, the Ayurvedic herb Hemidesmus Indicus, as well as other ingredients to induce sleep, prolong REM sleep, promote vivid and lucid dreams, and increase dream recall.

References:
[1] Kincl FA, Dorfman RI. Anabolic-androgenic potency of various steroids in a castrated rat assay. Steroids. 1964;3(1):109–22
[2] Raivio KO. Adenosine Deaminase /Ada/ and Purine Metabolism in Human Lymphocytes. Pediatr Res. 1975 Nov;9(11):869–869.
[3] Möser GH, Schrader J, Deussen A. Turnover of adenosine in plasma of human and dog blood. Am. J. Physiol. 1989 Apr;256(4 Pt 1):C799–806.

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