New products from Antaeus Labs and Prototype Nutrition

Antaeus Labs – best known for their innovative designer steroid products Trenazone, Ultradrol, and Mechabol – have just released their new stimulant product Axon.

Meanwhile Patrick Arnold’s benchtop brand Prototype Nutrition are preparing to add two new sprays to their already bulging topical lineup: A DHEA spray, and a pregnenolone spray will be joining their existing offerings of resveratrol, 7-keto DHEA/beta-androstenetriol, and 11-ketotestosterone sprays in the near future.

Antaeus Labs’ new stim is based on an extract of the plant Hedera Helix; the active triterpene Hederagenin has recently been found to be a non-selective reuptake inhibitor. [1]

Hederagenin

Unlike “SSRIs”, the anti-depressant medications intended to specifically inhibit the reuptake of serotonin, the naturally-occurring active ingredient in Axon hederagenin also inhibits the reuptake of several other monoamines, leading to increased levels of serotonin, dopamine, and norepinephrine (noradrenaline). This is intended to cause increased metabolism, energy levels, improved mood, and heightened focus – all useful things in the sporting or weightlifting environment.

Pregnenolone

Pregnenolone, the active in Prototype Nutrition’s new topical, is not only the “prohormone” to all endogenous steroids, it’s also a potent neurosteroid. Although much of what is produced testicularly will be transformed into other endogenous compounds before reaching circulation, a topical delivery system should ensure pharmocologically relevant doses of the natural steroid that is believed to be important for cognitive function, memory, and sleep. [2][3][4]

References
1. Jin, Z.-L., N. Gao, D. Zhou, et al. 2012. The extracts of Fructus Akebiae, a preparation containing 90% of the active ingredient hederagenin: serotonin, norepinephrine and dopamine reuptake inhibitor. Pharmacology, Biochemistry, and Behavior 100, 431–439.
2. Flood, J. F., J. E. Morley & E. Roberts 1992. Memory-enhancing effects in male mice of pregnenolone and steroids metabolically derived from it. Proceedings of the National Academy of Sciences of the United States of America 89, 1567–1571.
3. Mayo, W., O. George, S. Darbra, et al. 2003. Individual differences in cognitive aging: implication of pregnenolone sulfate. Progress in Neurobiology 71, 43–48.
4. Vallée, M., W. Mayo & M. Le Moal 2001. Role of pregnenolone, dehydroepiandrosterone and their sulfate esters on learning and memory in cognitive aging. Brain Research. Brain Research Reviews 37, 301–312.