The first of a series of articles on unusual and experimental steroids looks at the effects of adding an adamantoate ester to a steroid. Continue reading
Pharma Labs sell a few bodybuilding products, primarily on the UK supplement market. They’re stocked in gyms, shops and online stores, but the ingredients they list can cause some head-scratching.
Aside from their oft-exploited anti-inflammatory properties, glucocorticoids such as cortisol have number of other effects. They inhibit the uptake of glucose into muscle, shift homeostasis into a catabolic state, and promote the deposition of fat.
High levels of glucocorticoids cause visceral obesity (fat around the internal abdominal organs), insulin resistance, type 2 diabetes, adverse cholesterol levels, high blood pressure, and cardiac problems; so called “metabolic syndrome”.
Palmitoylethanolamide (PEA) is a naturally-occurring anti-inflammatory and analgesic fatty acid amide. PEA is formed locally at sites of tissue inflammation as a defense and repair reaction. It modulates mast cell activity (hyperactive in inflammatory conditions) and activated glia cells (non-neuronal brain cells).
An interesting paper on palmitoylethanolamide (PEA) was published recently in the Journal of Pain Research. The author, Jan Keppel of the University of Witten/Herdecke in Germany, summarizes the advances in the scientific understanding of PEA and related compounds that occurred over the last 60 years or so, and makes a number of interesting observations, though some of the conclusions reached may be challenged.
Check out the video abstract below for a quick rundown, or read the full text here.
Dimethazine, dymethazine, Roxilon, mebolazine
As mentioned in our previous blog post FDA officials recently identified the presence of two well known designer steroids, dimethazine and superdrol, in Purity First’s Healthy Life Chemistry B-50 product.
Further FDA testing has noted the additional detection of traces of something they suspect to be “dimethyltestosterone” in Purity First’s “Multi-Mineral” and “Vitamin C” products.  Continue reading
In a rather spectacular – not to mention ironic – blunder, a Vitamin B supplement from a supplement company called “Purity First” appears to have been contaminated with the designer steroids Methasteron and Dimethazine. Methasteron, better known as Superdrol, became a scheduled drug in 2012.
The FDA has received reports of 29 adverse incidents associated with the use of Healthy Life Chemistry By Purity First B-50. These reports include fatigue, muscle cramping, and myalgia (muscle pain), as well as abnormal laboratory findings for liver and thyroid function, and cholesterol levels.
Females who used this product reported unusual hair growth and missed menstruation, and males who used the product reported impotence and findings of low testosterone.
Some of the cases reported have resulted in hospitalization, but there were no reports of death or acute liver failure.
While this is almost undoubtedly a horrible accident caused primarily by carelessness on the part of their (presumably) Chinese supplier or contract manufacturer (and their own failure to perform adequate testing), it’s likely to have unpleasant ramifications for the owners of the inappropriately named “Purity First”.
Several interesting new products have hit the supplement and prohormone markets recently. New prohormones available include desoxytestosterone acetate and norethandriol, and new supplements include the “pump product” triacetyladenosine, and the sleep/dream formula Oneiromancer.
Norethandriol is expected to act as a prohormone to norethandrolone (Nilevar).
Norethandriol has an anabolic:androgenic ratio of 400:20 vs. methyltestosterone by oral administration. 
A very limited supply is available as “Legio X” from Iron Legion.
Desoxytestosterone is the non-17a-methylated analogue of desoxymethyltestosterone. Desoxymethyltestosterone is better known as madol or pheraplex, so desoxytestosterone is sometimes referred to as “unmethylated phera”.
Desoxytestosterone has an anabolic:androgenic ratio of 160:60 vs. testosterone by subcutaneous injection. 
Desoxytestosterone acetate first appeared on the market as a component of AX’s “3-AD”, and is currently available to pre-order as a raw powder from PHF Supplements. The acetate ester will enhance solubility significantly.
Adenosine is a cellular signalling molecule that regulates muscular blood flow and glucose uptake. Adenosine itself has a very short half life and is readily subjected to metabolic inactivation by the enzyme adenosine deaminase.  The 3 acetyl groups of triacetyladenosine slow the rate of metabolism and elimination of the adenosine molecule in the body. These chemical changes also permit greater lipid solubility to allow for better accessibility to the body via a topical formulation.
Prototype Nutrition has recently introduced triacetyladenosine as a capped product for oral use. The ingredient can also be found in two of Patrick Arnold’s other formulations; E-Pharm Pump Spray and E-Pharm Joint Force.
Oneiromancer from Antaeus Labs is promoted as a dream/sleep supplement. It contains extracts of the shamanistic herbs Silene Capensis and Synaptolepis Kirkii, the Ayurvedic herb Hemidesmus Indicus, as well as other ingredients to induce sleep, prolong REM sleep, promote vivid and lucid dreams, and increase dream recall.
 Iriarte J, Djerassi C, Ringold HJ. Steroids. CVII.1 Δ5(6)-19-Nor Steroids, a New Class of Potent Anabolic Agents2. J. Am. Chem. Soc. 1959 Jan 1;81(2):436–8.
 Kincl FA, Dorfman RI. Anabolic-androgenic potency of various steroids in a castrated rat assay. Steroids. 1964;3(1):109–22
 Raivio KO. Adenosine Deaminase /Ada/ and Purine Metabolism in Human Lymphocytes. Pediatr Res. 1975 Nov;9(11):869–869.
 Möser GH, Schrader J, Deussen A. Turnover of adenosine in plasma of human and dog blood. Am. J. Physiol. 1989 Apr;256(4 Pt 1):C799–806.
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